JCM Catalogue

Streptomyces avermitilis Kim and Goodfellow 2002
Taxonomy in NCBI database: Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae.
5070T <-- KCC S-1070 <-- NRRL 8165 <-- Merck Sharp & Dohme Res. Labs.; MA-4680.
Accessioned in 1983.
=ATCC 31267 =BCRC 12382 =CECT 3280 =CGMCC 4.1807 =CGMCC 4.2072 =CIP 107838 =DSM 46492 =IFO 14893 =IMET 43778 =KCTC 9063 =KCTC 9698 =NBIMCC 3394 =NBRC 14893 =NCIMB 12804 =NRRL 8165 =VKM Ac-1301 =VTT E-042732.
Streptomyces avermectinius.
Type strain [5349].
Medium: 42, 50, 66;  Temperature: 28°C; Rehydration fluid: 656.   more information +  Full / Short version of the cataloguepage top

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Source: Soil, Kawana, Ito City, Shizuoka Pref., Japan [1418].
Biochemistry/Physiology: [1418,5349,5351].
Cell wall: LL-A2pm [5349,5351]; N-acetyl Mur [5351].
Fatty acid: [5351].
Quinone: MK-9(H6) [5349], MK-9(H6), MK-9(H8) [5351].
Polar lipid: PE [5351].
G+C (mol%): 70.3 (HPLC) [5351], 70.7 (genome sequence) [5438].
DNA-DNA relatedness: [5351].
Phylogeny: 16S rRNA gene (AB078897, AF145223) [5349,5351].
Genome sequence: AP005645 (plasmid SAP1), BA000030 (http://avermitilis.ls.kitasato-u.ac.jp/) [5207,5438], BAVY00000000 [10710], BJHY00000000, BJHX00000000, JZJK00000000, LMWT00000000.
Production: Avermectins [1418].
NCBI Assembly ID: GCA_000968255 (GenBank), GCF_000968255 (RefSeq).
BacDive ID: 16214.
NCBI Taxonomy ID: 33903.
Genomic DNA is available from RIKEN BRC-DNA Bank: JGD12254.
Publication(s) using this strain [A05212, A06243, A17582, A22390].
Patent publication(s) using this strain [WO2009/035107, WO/2014/013538 , WO/2015/022798 ].
 Related information on delivery / use of the strain
Biosafety level 1
Terms and conditions Not applicable
Export control (1) No
Distribution control in Japan (2) No
Genetically modified microorganism No
Technical information -
Additional information -
 (1) in complying with the Foreign Exchange and Foreign Trade Control Law of Japan
 (2) in complying with the Plant Protection Law of Japan

 Delivery category
Domestic A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Overseas A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Viability and purity assays of this product were performed at the time of production as part of quality control. The authenticity of the culture was confirmed by analyzing an appropriate gene sequence, e.g., the 16S rRNA gene for prokaryotes, the D1/D2 region of LSU rRNA gene, the ITS region of the nuclear rRNA operon, etc. for eukaryotes. The characteristics and/or functions of the strain appearing in the catalogue are based on information from the corresponding literature and JCM does not guarantee them.
18239 <-- H. Ikeda SUKA2 [Δ(7,7341-1,494,898 nt), ΔolmA (Δ3,557,725-3,594,005 nt)].
Accessioned in 2012.
Medium: 42;  Temperature: 28°C; Rehydration fluid: 656.   more information +
More information: Large-deletion mutant [8966].
BacDive ID: 162203.
 Related information on delivery / use of the strain
Biosafety level 1 -
Terms and conditions Imposed
Export control (1) No -
Distribution control in Japan (2) No -
Genetically modified microorganism Yes
Technical information - -
Additional information - -
 (1) in complying with the Foreign Exchange and Foreign Trade Control Law of Japan
 (2) in complying with the Plant Protection Law of Japan

 Delivery category
Domestic A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Overseas A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Viability and purity assays of this product were performed at the time of production as part of quality control but note that the authenticity has not yet been checked by gene sequencing. The characteristics and/or functions of the strain appearing in the catalogue are based on information from the corresponding literature and JCM does not guarantee them.
18240 <-- H. Ikeda SUKA3 [Δ(79,455-1,595,563 nt)::loxP].
Accessioned in 2012.
Medium: 42;  Temperature: 28°C; Rehydration fluid: 656.   more information +
More information: Large-deletion mutant [8966].
BacDive ID: 162204.
 Related information on delivery / use of the strain
Biosafety level 1 -
Terms and conditions Imposed
Export control (1) No -
Distribution control in Japan (2) No -
Genetically modified microorganism Yes
Technical information - -
Additional information - -
 (1) in complying with the Foreign Exchange and Foreign Trade Control Law of Japan
 (2) in complying with the Plant Protection Law of Japan

 Delivery category
Domestic A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Overseas A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Viability and purity assays of this product were performed at the time of production as part of quality control but note that the authenticity has not yet been checked by gene sequencing. The characteristics and/or functions of the strain appearing in the catalogue are based on information from the corresponding literature and JCM does not guarantee them.
18241 <-- H. Ikeda SUKA4 [Δ(7,7341-1,494,898 nt), Δ(olmA4-olmC)::mut-loxP (Δ3,536,700-3,634,730 nt)].
Accessioned in 2012.
Medium: 42;  Temperature: 28°C; Rehydration fluid: 656.   more information +
More information: Large-deletion mutant [8966].
BacDive ID: 162205.
 Related information on delivery / use of the strain
Biosafety level 1 -
Terms and conditions Imposed
Export control (1) No -
Distribution control in Japan (2) No -
Genetically modified microorganism Yes
Technical information - -
Additional information - -
 (1) in complying with the Foreign Exchange and Foreign Trade Control Law of Japan
 (2) in complying with the Plant Protection Law of Japan

 Delivery category
Domestic A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Overseas A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Viability and purity assays of this product were performed at the time of production as part of quality control but note that the authenticity has not yet been checked by gene sequencing. The characteristics and/or functions of the strain appearing in the catalogue are based on information from the corresponding literature and JCM does not guarantee them.
18242 <-- H. Ikeda SUKA5 [Δ(79,455-1,595,563 nt)::loxP, Δ(olmA4-olmC)::mut-loxP (Δ3,536,700-3,634,730 nt)].
Accessioned in 2012.
Medium: 42;  Temperature: 28°C; Rehydration fluid: 656.   more information +
More information: Large-deletion mutant [8966].
BacDive ID: 162206.
 Related information on delivery / use of the strain
Biosafety level 1 -
Terms and conditions Imposed
Export control (1) No -
Distribution control in Japan (2) No -
Genetically modified microorganism Yes
Technical information - -
Additional information - -
 (1) in complying with the Foreign Exchange and Foreign Trade Control Law of Japan
 (2) in complying with the Plant Protection Law of Japan

 Delivery category
Domestic A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Overseas A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Viability and purity assays of this product were performed at the time of production as part of quality control but note that the authenticity has not yet been checked by gene sequencing. The characteristics and/or functions of the strain appearing in the catalogue are based on information from the corresponding literature and JCM does not guarantee them.
18243 <-- H. Ikeda SUKA6 [Δ(7,7341-1,494,898 nt), Δ(olmA4-olmC)::mut-loxP (Δ3,536,700-3,634,730 nt), Δ(8,886,025-8,925,414 nt)::loxP].
Accessioned in 2012.
Medium: 42;  Temperature: 28°C; Rehydration fluid: 656.   more information +
More information: Large-deletion mutant [8966].
BacDive ID: 162207.
 Related information on delivery / use of the strain
Biosafety level 1 -
Terms and conditions Imposed
Export control (1) No -
Distribution control in Japan (2) No -
Genetically modified microorganism Yes
Technical information - -
Additional information - -
 (1) in complying with the Foreign Exchange and Foreign Trade Control Law of Japan
 (2) in complying with the Plant Protection Law of Japan

 Delivery category
Domestic A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Overseas A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Viability and purity assays of this product were performed at the time of production as part of quality control but note that the authenticity has not yet been checked by gene sequencing. The characteristics and/or functions of the strain appearing in the catalogue are based on information from the corresponding literature and JCM does not guarantee them.
18244 <-- H. Ikeda SUKA7 [Δ(79,455-1,595,563 nt)::loxP, Δ(olmA4-olmC)::mut-loxP (Δ3,536,700-3,634,730 nt), Δ(8,886,025-8,925,414 nt)::loxP].
Accessioned in 2012.
Medium: 42;  Temperature: 28°C; Rehydration fluid: 656.   more information +
More information: Large-deletion mutant [8966].
BacDive ID: 162208.
 Related information on delivery / use of the strain
Biosafety level 1 -
Terms and conditions Imposed
Export control (1) No -
Distribution control in Japan (2) No -
Genetically modified microorganism Yes
Technical information - -
Additional information - -
 (1) in complying with the Foreign Exchange and Foreign Trade Control Law of Japan
 (2) in complying with the Plant Protection Law of Japan

 Delivery category
Domestic A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Overseas A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Viability and purity assays of this product were performed at the time of production as part of quality control but note that the authenticity has not yet been checked by gene sequencing. The characteristics and/or functions of the strain appearing in the catalogue are based on information from the corresponding literature and JCM does not guarantee them.
18245 <-- H. Ikeda SUKA10 [Δ(7,7341-1,494,898 nt), Δ(olmA4-olmC)::mut-loxP (Δ3,536,700-3,634,730 nt), Δ(gap1-ptlL)::ermE (Δ3,745,502-3,758,936 nt)].
Accessioned in 2012.
Medium: 42;  Temperature: 28°C; Rehydration fluid: 656.   more information +
More information: Large-deletion mutant [8966].
BacDive ID: 162209.
 Related information on delivery / use of the strain
Biosafety level 1 -
Terms and conditions Imposed
Export control (1) No -
Distribution control in Japan (2) No -
Genetically modified microorganism Yes
Technical information - -
Additional information - -
 (1) in complying with the Foreign Exchange and Foreign Trade Control Law of Japan
 (2) in complying with the Plant Protection Law of Japan

 Delivery category
Domestic A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Overseas A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Viability and purity assays of this product were performed at the time of production as part of quality control but note that the authenticity has not yet been checked by gene sequencing. The characteristics and/or functions of the strain appearing in the catalogue are based on information from the corresponding literature and JCM does not guarantee them.
18246 <-- H. Ikeda SUKA11 [Δ(79,455-1,595,563 nt)::loxP, Δ(olmA4-olmC)::mut-loxP (Δ3,536,700-3,634,730 nt), Δ(gap1-ptlL)::ermE (Δ3,745,502-3,758,936 nt)].
Accessioned in 2012.
Medium: 42;  Temperature: 28°C; Rehydration fluid: 656.   more information +
More information: Large-deletion mutant [8966].
BacDive ID: 162210.
 Related information on delivery / use of the strain
Biosafety level 1 -
Terms and conditions Imposed
Export control (1) No -
Distribution control in Japan (2) No -
Genetically modified microorganism Yes
Technical information - -
Additional information - -
 (1) in complying with the Foreign Exchange and Foreign Trade Control Law of Japan
 (2) in complying with the Plant Protection Law of Japan

 Delivery category
Domestic A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Overseas A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Viability and purity assays of this product were performed at the time of production as part of quality control but note that the authenticity has not yet been checked by gene sequencing. The characteristics and/or functions of the strain appearing in the catalogue are based on information from the corresponding literature and JCM does not guarantee them.
18247 <-- H. Ikeda SUKA12 [Δ(7,7341-1,494,898 nt), Δ(olmA4-olmC)::mut-loxP (Δ3,536,700-3,634,730 nt), Δ(gap1-ptlL)::ermE (Δ3,745,502-3,758,936 nt), Δ(8,886,025-8,925,414 nt)::loxP].
Accessioned in 2012.
Medium: 42;  Temperature: 28°C; Rehydration fluid: 656.   more information +
More information: Large-deletion mutant [8966].
BacDive ID: 162211.
 Related information on delivery / use of the strain
Biosafety level 1 -
Terms and conditions Imposed
Export control (1) No -
Distribution control in Japan (2) No -
Genetically modified microorganism Yes
Technical information - -
Additional information - -
 (1) in complying with the Foreign Exchange and Foreign Trade Control Law of Japan
 (2) in complying with the Plant Protection Law of Japan

 Delivery category
Domestic A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Overseas A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Viability and purity assays of this product were performed at the time of production as part of quality control but note that the authenticity has not yet been checked by gene sequencing. The characteristics and/or functions of the strain appearing in the catalogue are based on information from the corresponding literature and JCM does not guarantee them.
18248 <-- H. Ikeda SUKA13 [Δ(79,455-1,595,563 nt)::loxP, Δ(olmA4-olmC)::mut-loxP (Δ3,536,700-3,634,730 nt), Δ(gap1-ptlL)::ermE (Δ3,745,502-3,758,936 nt), Δ(8,886,025-8,925,414 nt)::loxP].
Accessioned in 2012.
Medium: 42;  Temperature: 28°C; Rehydration fluid: 656.   more information +
More information: Large-deletion mutant [8966].
BacDive ID: 162212.
 Related information on delivery / use of the strain
Biosafety level 1 -
Terms and conditions Imposed
Export control (1) No -
Distribution control in Japan (2) No -
Genetically modified microorganism Yes
Technical information - -
Additional information - -
 (1) in complying with the Foreign Exchange and Foreign Trade Control Law of Japan
 (2) in complying with the Plant Protection Law of Japan

 Delivery category
Domestic A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Overseas A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Viability and purity assays of this product were performed at the time of production as part of quality control but note that the authenticity has not yet been checked by gene sequencing. The characteristics and/or functions of the strain appearing in the catalogue are based on information from the corresponding literature and JCM does not guarantee them.
18249 <-- H. Ikeda SUKA15 [Δ(7,7341-1,494,898 nt), Δ(olmA4-olmC)::mut-loxP (Δ3,536,700-3,634,730 nt), Δ(gap1-ptlL)::ermE (Δ3,745,502-3,758,936 nt), Δ(8,886,025-8,925,414 nt)::loxP, ΔgeoA::aadA].
Accessioned in 2012.
Medium: 42;  Temperature: 28°C; Rehydration fluid: 656.   more information +
More information: Large-deletion mutant [8966].
BacDive ID: 162213.
 Related information on delivery / use of the strain
Biosafety level 1 -
Terms and conditions Imposed
Export control (1) No -
Distribution control in Japan (2) No -
Genetically modified microorganism Yes
Technical information - -
Additional information - -
 (1) in complying with the Foreign Exchange and Foreign Trade Control Law of Japan
 (2) in complying with the Plant Protection Law of Japan

 Delivery category
Domestic A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Overseas A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Viability and purity assays of this product were performed at the time of production as part of quality control but note that the authenticity has not yet been checked by gene sequencing. The characteristics and/or functions of the strain appearing in the catalogue are based on information from the corresponding literature and JCM does not guarantee them.
18250 <-- H. Ikeda SUKA16 [Δ(79,455-1,595,563 nt)::loxP, Δ(olmA4-olmC)::mut-loxP (Δ3,536,700-3,634,730 nt), Δ(gap1-ptlL)::ermE (Δ3,745,502-3,758,936 nt), Δ(8,886,025-8,925,414 nt)::loxP, ΔgeoA::aadA].
Accessioned in 2012.
Medium: 42;  Temperature: 28°C; Rehydration fluid: 656.   more information +
More information: Large-deletion mutant [8966].
BacDive ID: 162214.
 Related information on delivery / use of the strain
Biosafety level 1 -
Terms and conditions Imposed
Export control (1) No -
Distribution control in Japan (2) No -
Genetically modified microorganism Yes
Technical information - -
Additional information - -
 (1) in complying with the Foreign Exchange and Foreign Trade Control Law of Japan
 (2) in complying with the Plant Protection Law of Japan

 Delivery category
Domestic A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Overseas A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Viability and purity assays of this product were performed at the time of production as part of quality control but note that the authenticity has not yet been checked by gene sequencing. The characteristics and/or functions of the strain appearing in the catalogue are based on information from the corresponding literature and JCM does not guarantee them.
18251 <-- H. Ikeda SUKA17 [Δ(79,455-1,595,563 nt)::loxP, Δ(olmA4-olmC)::mut-loxP (Δ3,536,700-3,634,730 nt), Δ(gap1-ptlL)::ermE (Δ3,745,502-3,758,936 nt), Δ(8,886,025-8,925,414 nt)::loxP, Δ(2,633,682-2,641,994 nt)::mut-loxP].
Accessioned in 2012.
Medium: 42;  Temperature: 28°C; Rehydration fluid: 656.   more information +
More information: Large-deletion mutant [8966].
BacDive ID: 162215.
Patent publication(s) using this strain [WO/2015/022798 , WO2017/150304].
 Related information on delivery / use of the strain
Biosafety level 1 -
Terms and conditions Imposed
Export control (1) No -
Distribution control in Japan (2) No -
Genetically modified microorganism Yes
Technical information - -
Additional information - -
 (1) in complying with the Foreign Exchange and Foreign Trade Control Law of Japan
 (2) in complying with the Plant Protection Law of Japan

 Delivery category
Domestic A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Overseas A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Viability and purity assays of this product were performed at the time of production as part of quality control but note that the authenticity has not yet been checked by gene sequencing. The characteristics and/or functions of the strain appearing in the catalogue are based on information from the corresponding literature and JCM does not guarantee them.
18252 <-- H. Ikeda SUKA18 [Δ(79,455-1,595,563 nt)::loxP, Δ(olmA4-olmC)::mut-loxP (Δ3,536,700-3,634,730 nt), Δ(gap1-ptlL)::ermE (Δ3,745,502-3,758,936 nt), Δ(8,886,025-8,925,414 nt)::loxP, Δ(2,633,682-2,641,994 nt)::mut-loxP, rpsL (G129C; K43N)].
Accessioned in 2012.
Medium: 42;  Temperature: 28°C; Rehydration fluid: 656.   more information +
More information: Large-deletion mutant [8966].
BacDive ID: 162216.
 Related information on delivery / use of the strain
Biosafety level 1 -
Terms and conditions Imposed
Export control (1) No -
Distribution control in Japan (2) No -
Genetically modified microorganism Yes
Technical information - -
Additional information - -
 (1) in complying with the Foreign Exchange and Foreign Trade Control Law of Japan
 (2) in complying with the Plant Protection Law of Japan

 Delivery category
Domestic A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Overseas A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Viability and purity assays of this product were performed at the time of production as part of quality control but note that the authenticity has not yet been checked by gene sequencing. The characteristics and/or functions of the strain appearing in the catalogue are based on information from the corresponding literature and JCM does not guarantee them.
18253 <-- H. Ikeda SUKA19 [Δ(79,455-1,595,563 nt)::loxP, Δ(olmA4-olmC)::mut-loxP (Δ3,536,700-3,634,730 nt), Δ(gap1-ptlL)::ermE (Δ3,745,502-3,758,936 nt), Δ(8,886,025-8,925,414 nt)::loxP, Δ(2,633,682-2,641,994 nt)::mut-loxP, rpsL (A128T; K43M)].
Accessioned in 2012.
Medium: 42;  Temperature: 28°C; Rehydration fluid: 656.   more information +
More information: Large-deletion mutant [8966].
BacDive ID: 162217.
 Related information on delivery / use of the strain
Biosafety level 1 -
Terms and conditions Imposed
Export control (1) No -
Distribution control in Japan (2) No -
Genetically modified microorganism Yes
Technical information - -
Additional information - -
 (1) in complying with the Foreign Exchange and Foreign Trade Control Law of Japan
 (2) in complying with the Plant Protection Law of Japan

 Delivery category
Domestic A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Overseas A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Viability and purity assays of this product were performed at the time of production as part of quality control but note that the authenticity has not yet been checked by gene sequencing. The characteristics and/or functions of the strain appearing in the catalogue are based on information from the corresponding literature and JCM does not guarantee them.
18254 <-- H. Ikeda SUKA20 [Δ(79,455-1,595,563 nt)::loxP, Δ(olmA4-olmC)::mut-loxP (Δ3,536,700-3,634,730 nt), Δ(gap1-ptlL)::ermE (Δ3,745,502-3,758,936 nt), Δ(8,886,025-8,925,414 nt)::loxP, Δ(2,633,682-2,641,994 nt)::mut-loxP, rpsL (A128G; K43R)].
Accessioned in 2012.
Medium: 42;  Temperature: 28°C; Rehydration fluid: 656.   more information +
More information: Large-deletion mutant [8966].
BacDive ID: 162218.
 Related information on delivery / use of the strain
Biosafety level 1 -
Terms and conditions Imposed
Export control (1) No -
Distribution control in Japan (2) No -
Genetically modified microorganism Yes
Technical information - -
Additional information - -
 (1) in complying with the Foreign Exchange and Foreign Trade Control Law of Japan
 (2) in complying with the Plant Protection Law of Japan

 Delivery category
Domestic A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Overseas A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Viability and purity assays of this product were performed at the time of production as part of quality control but note that the authenticity has not yet been checked by gene sequencing. The characteristics and/or functions of the strain appearing in the catalogue are based on information from the corresponding literature and JCM does not guarantee them.
18255 <-- H. Ikeda SUKA21 [Δ(79,455-1,595,563 nt)::loxP, Δ(olmA4-olmC)::mut-loxP (Δ3,536,700-3,634,730 nt), Δ(gap1-ptlL)::ermE (Δ3,745,502-3,758,936 nt), Δ(8,886,025-8,925,414 nt)::loxP, Δ(2,633,682-2,641,994 nt)::mut-loxP, rpsL (A262G; K88E)].
Accessioned in 2012.
Medium: 42;  Temperature: 28°C; Rehydration fluid: 656.   more information +
More information: Large-deletion mutant [8966].
BacDive ID: 162219.
 Related information on delivery / use of the strain
Biosafety level 1 -
Terms and conditions Imposed
Export control (1) No -
Distribution control in Japan (2) No -
Genetically modified microorganism Yes
Technical information - -
Additional information - -
 (1) in complying with the Foreign Exchange and Foreign Trade Control Law of Japan
 (2) in complying with the Plant Protection Law of Japan

 Delivery category
Domestic A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Overseas A (Freeze-dried or L-dried culture) or C (Actively growing culture on request)
Viability and purity assays of this product were performed at the time of production as part of quality control but note that the authenticity has not yet been checked by gene sequencing. The characteristics and/or functions of the strain appearing in the catalogue are based on information from the corresponding literature and JCM does not guarantee them.
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